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Cake day: March 31st, 2025

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  • DCM is also about the only good solvent left that is also resistant to lewis acids. I think that some people were pushing for benzotrifluoride as a replacement, but it just straight up doesn’t work as well where i tried it

    Tbf before “do it in DCM” was “do it in CCL4” or “do it in benzene”, DCM just works without nuking operator’s liver

    Lots of these new green solvents are also annoyingly polar so perhaps they can be used as replacements of other polar solvents but not anything else. I’m not using cyrene, fuck that

    TFA is used because it works and is shelf-stable. Replacements like HCl in ether or ethyl acetate are bitch to make and when these can be bought, they have to be refrigerated all the way. Straight up not worth the effort on small scale











  • now you have it straight from source:

    e/acc, distinct from EA, is a rival ideology about technology.

    (somewhere in this mix someone called me e/acc. i am not. if you’re going to classify me in this space, i am something like a Kurzweilian h+

    e/acc is a troll ideology for upsetting EA people and scamming pmarca.)

    then he complains about sneerclub for some reason, damn i can’t guess why

    if anyone has Rat Explainer For Normal People 101, not written by weirdos (derogatory) that would be useful i think now that what is known here for decade broke into mainstream

    LLMs doing Great Things Worth Ruining The World Over in medical research

    there are entire wet labs whose software stack predates openai. go and ask anyone who works in a moderately long operating lab if there’s any load bearing Thing that runs under windows xp control or older (there will be). there are some extremely limited applications of pre-llm ml in drug design, but it’s trained on entirely different type of data and it does entirely different thing and i’d say it’s not load bearing. these things are expected to be fed with new data from testing new things provided in previous iterations and if you hit something you’ll get there on your own. all of that data is noisy