The only cheating method that can’t be beaten reliably with any form of client side anti-cheat uses PCIe. The gaming PC gets a PCIe card that sends over data on RAM to a second PC over USB. That PC then turns all that data into useable info, and USBs it back to the gaming PC in the form of cheats/hacks.
I hope i got all that right, friend works in the industry and is studying this stuff. I can mostly keep up with all the things they tell me.
The woman in grey, in the middle of the thumbnail, looks like she had surgery done to look like the gigachad meme.